Naveen Jain on the Human Ecosystem and Personalized Optimization of Your Gut Health

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Katie: Good day and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the top. And I’m right here at present with my buddy, Naveen, who’s an intensely curious entrepreneur who has been taking over some massive, audacious concepts to push humanity ahead. He’s the creator of the award-winning e-book “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Categorical, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Sensible, amongst others.

And his present work is in Viome Life Sciences, which was based in 2016 with a mission of constructing sickness non-compulsory by predicting and stopping power illness by way of a deeper understanding of a person’s biology at a molecular degree. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to stop and reverse power illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the 12 months, Most Inventive Individual by Quick Firm, High 20 Entrepreneurs, and lots of extra.

On this episode, we discuss in regards to the human ecosystem and customized optimization of your intestine well being and your total well being. We discuss in regards to the cause the intestine impacts your complete physique. Why it’s not simply genetics from our mother and father however really our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome steadiness begins at start and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.

The distinction between DNA and gene expression. How some meals may be good for some folks and never others, and tips on how to know which is finest for you, but additionally, the universally dangerous meals. Why there are some universality unhealthy ones however not universally good ones. Why he doesn’t suggest harsh merchandise that kill micro organism within the mouth or within the intestine. The true cause it’s essential to chew your meals rather well earlier than swallowing, and a lot extra. Lot’s of sensible data on this episode. Additionally, a lot of hyperlinks to be taught extra within the present notes at wellnessmama.fm, so examine these out. However with out additional ado, let’s be part of Naveen Jain. Naveen, welcome again.

Naveen: Properly, Katie, so good to see you lastly after a protracted, very long time.

Katie: I’m so excited we get to have a dialog and get to file it and share it at present, and we’re gonna discuss quite a bit about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I might say you’re the one individual I do know in actual life who has a Moon rock assortment. And so, I might love so that you can simply speak about this as a result of I feel you’re my solely hobbyist Moon rock collector.

Naveen: Properly, I feel, Katie, you recognize, to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a means of expressing that there’s nothing that’s not possible for us to do. Although it’s known as “Moonshots” that individuals thought was troublesome, if not not possible to do and having, you recognize, now to have the ability to go to the Moon and to me, the gathering of house rocks really was simply merely a interest of in a position to maintain one thing in your hand. Which may be even earlier than the start of our planet. And it provides you some thought of how fragile we’re that if we don’t maintain ourselves, our planet, we as humanity might not survive. As a species, we might not survive.

So, you recognize, thought of when somebody says, “I’m actually apprehensive about our planet,” ask the planet and planet will inform you, “Don’t you are concerned about me as a result of we…” Planet will do exactly high-quality however human species might not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are related collectively. When one thing outdoors us goes improper, we as inside ecosystem may also be impacted, proper. And that’s coming right down to, you recognize, in the event you have a look at what’s above, so under is absolutely what’s outdoors the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.

Katie: I like that you just mentioned it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and you recognize him as nicely. And I requested him that query. You recognize, your technology’s gonna face quite a bit within the environmental and local weather stuff. And, I raised this query and he goes, “Properly, mother, you’re really asking the improper query as a result of the…”

Naveen: Oh, I find it irresistible, I find it irresistible.

Katie: He mentioned, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we have to be asking how we may be extra synergistic inside an surroundings that’s greater than us.”

Naveen: That’s the good reply. That’s precisely how I might see it that…you recognize, when folks say, “Aren’t you apprehensive in regards to the planet?” I say, “That’s not the query you need to be asking.” It’s, “Are we apprehensive in regards to the human species?” That’s what we ought to be asking.

Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I might say not apprehensive about however working to unravel. My listeners are fairly well being savvy and perceive or a minimum of have a passing understanding that intestine well being impacts the entire whole physique. However I really feel like this idea is…nicely, we’ve identified points of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…due to corporations like Viome, now we have many extra tangible instruments to truly perceive and begin to do one thing about that. However to begin broad, type of give us an summary of what we imply by the well being of the intestine impacts the well being of the entire physique.

Naveen: So, nicely, to start with, you recognize, let’s simply begin from the start. We as human beings should not merely a product of the DNA from our mother and pop. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which can be really expressed in our human physique should not our personal. They arrive from these microbes which can be in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we have a look at the human beings as such when it comes to all of the genes which can be expressed that makes us who we’re, they don’t seem to be people. They’re largely microbial. We’re dwelling of their world. They don’t reside in our world, proper.

So, once we perceive that, you recognize, regardless that you might argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you might argue sometime that perhaps they really created us to unfold them round, perhaps they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and cozy place to remain. In flip, they feed us the vitamins that our physique wants to truly be wholesome, proper. So, think about from the time a child is born, and I feel that is one thing that most individuals don’t understand, that within the first couple of days of mom’s breast milk is filled with oligosaccharides. And that can’t be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Meaning it’s to create the ecosystem inside us.

Now think about what nature is telling us, that we simply created a offspring and one of the simplest ways to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes by way of the start canal, that is the primary publicity the child will get to the entire world of microbiome. It will get…utterly inhales the microbiome because the child’s going by way of start canal. And sadly, among the moms for apparent causes find yourself getting a C-section. They really…the infants should not going by way of the identical…they’re uncovered to pores and skin microbiome fairly by way of the start canal, the microbiome that they might get by way of the start canal. And that could be a basically…the child, when it’s born, is definitely…the character has created in a means that the microbes get launched into the child on the time of the start and that truly now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.

And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I feel that is the basic half that individuals want to know. Seventy % of our immune system is alongside our intestine lining. In truth, all of the analysis exhibits that how intestine microbiome is continually coaching our immune system what’s a buddy and what’s a foe, proper. So, in some sense, in the event you have a look at the human physique, there’s a tube that goes by way of us. There’s a high of the tube in your mouth after which there’s the underside of the tube, and then you definitely begin to take a look at all alongside the traces there’s a large quantity of microbial existence there. They usually in reality are always interacting with our immune system and the immune system is now understanding when there may be really a pathogen that’s coming by way of the meals or the pathogen that’s coming by way of the surface world, tips on how to react to it. And these microbes are the primary sign that tells the immune programs, “This isn’t good. Go do one thing about it, proper.”

And I feel to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I feel as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we minimize our pores and skin or whether or not there may be some kind of pathogen or we get some kind of a illness, it usually is designed to heal itself if our physique is in steadiness. So, when there are intestine microbial actions and the human host are always in sync and wholesome and our immune system is wholesome, then our physique will really heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique just isn’t relaxed, you get illness which we name illness.

Katie: Yeah, so many essential factors you simply mentioned to unpack. And I feel the primary being that we actually are extra bacterial than human and also you…right here you mentioned you’re what you eat but it surely goes thus far past that. It’s not even you’re what you eat and even you’re what you eat-eat, however what your intestine micro organism eats and the way it grows. And I like that you just introduced up the start canal factor as a result of I’m a doula and I’ve really helped in a number of C-section births with feeding the child, as a result of such as you mentioned, in the event you don’t…the child is of course meant to seed their intestine by way of the start canal. And if that doesn’t occur, such as you mentioned, they’re seeding to the hospital room, to pores and skin, to probably disinfectants which can be in that room, all types of issues. And we all know that this intestine micro organism at start, increasingly we be taught, units you up to your complete life. But in addition, the excellent news is…and I do know that Viome does a whole lot of analysis on this. All just isn’t misplaced in the event you don’t get an ideal begin. We now have the power to type of get a snapshot and look within the intestine in a extremely distinctive means after which optimize to enhance somebody’s well being going ahead.

And in addition, such as you mentioned, the physique’s pure state is well being. It’s not usually that we have to do something drastic. We have to get out of our personal means and simply take away the issues which can be conserving the physique from being wholesome or perhaps generally give it little further vitamins to assist get there. Speak slightly bit in regards to the science of Viome and what we’re testing as a result of this know-how didn’t even exist a pair many years in the past, and now now we have such superb knowledge from this.

Naveen: Properly, it’s very fascinating is this concept of, you recognize…in the event you return and have a look at couple of many years in the past, it was really the micro organism and all these organisms have been thought of as an enemy of the human physique. That’s the minute you see them, your job is to kill them as rapidly as attainable as a result of they will’t presumably be there for our good, proper. And as we began to be taught extra in regards to the human physique, we realized that the majority of those organisms are literally commensal. They’re presupposed to be there they usually in reality…once we feed them issues like, you recognize…in olden days, once we have been dwelling within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the foundation and eat it. That’s stuffed with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, really flip them into brief chain fatty acids. Issues like butyric, issues like acetate, these have been all of the vitamins that our physique wanted.

In truth, in the event you begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, in the event you actually take into consideration all of the issues which can be being executed within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it really impacts the entire physique together with our mind to coming again to it, Katie, that you just identified. What occurs in our intestine impacts our temper. So, whether or not it’s a melancholy or nervousness or, you recognize, you may name them any names you need, you recognize, lots of these items together with autism is now related instantly into the intestine microbiome. In truth, they’ve executed now the analysis the place they did merely a microbial transplant known as a fecal transplant they usually have been in a position to in reality present that youngsters with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They have been in a position to present if you took an individual that has a melancholy a microbial transplant or nervousness, it may be transferred just by transferring the microbiome into one other species. They usually’ve executed them in mice they usually’ve executed that in reality in people, and clearly, it was executed by mistake however that’s really the way it occurred.

In truth, what’s actually fascinating is dependancy. They usually’ve proven the identical factor. They took…there have been 17 folks on the analysis that have been utterly hooked on alcohol. And people folks, they gave them a fecal transplant from individuals who really had no dependancy. And these folks’s dependancy went away. Now think about that, that our intestine microbiome are controlling our mind when it comes to what to do. That’s what the dependancy is, proper. And I feel that’s actually phenomenal.

And now what we’re studying is each kind of most cancers…in reality what they’ve now checked out is each single strong tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there may be microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism desirous to survive would ever show a microbial peptide except it’s there to idiot our immune system into pondering that is self and protects the tumor towards the immune system attacking, proper?

Now, think about what…one other factor that’s most fascinating I discovered was if you do immunotherapy, it really works about one-third of the time. And the folks the place the immunotherapy doesn’t work, within the 70% of the those who immunotherapy didn’t work, they merely have been in a position to do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome just isn’t solely there to maintain us wholesome from all of the illnesses at present we name the completely different names. Coronary heart illnesses, it’s coming from our intestine microbes really producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. In truth, we will now have a look at issues like LDL manufacturing which is a foul ldl cholesterol manufacturing and see how microbial actions and microbial metabolites really change the LDL manufacturing. You’re ready to take a look at how…what’s occurring in your intestine, how are we altering the inflammatory markers in our host. So, we’re in a position to measure the intestine exercise and the human host exercise, all their cytokines. So, we’re taking a look at each interleukins, we’re taking a look at the entire inflammatory markers to see how they’re altering with the intestine microbial exercise.

And so, anyway, the purpose I’m attempting to make is that you just talked about one thing about these micro organism, and I simply need folks to know the microorganisms should not simply micro organism. They’re predominantly micro organism however additionally they encompass yeast, viruses and even the RNA viruses or fungus or mildew. All of these items are literally the entire ecosystem and the most important half in reality in the event you observed nearly 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And in the event you have a look at any nature whether or not you’re wanting within the swamp otherwise you’re wanting on the intestine microbiome, in reality there are 10 instances extra phages than the micro organism alone. And meaning these viruses that infect micro organism are modifying the bacterial…the organism, the features of those micro organism that in reality modifications how these micro organism behave when it comes to what features they’re performing.

So once more, what’s actually fascinating is by taking a look at what organisms are there, won’t ever inform you what’s going on in your physique. In truth, their features are what makes the distinction. Meaning what they’re producing can…is absolutely the one factor that issues what these intestine microbes are producing, not who they’re. And I feel, Katie, you in all probability know that a whole lot of the folks like Akkermansia muciniphila. Among the corporations are promoting them as a probiotic with out realizing that Akkermansia may be good for some folks and in reality it’s the primary cause for inflicting a number of sclerosis, and it has additionally been instantly linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one individual and might do one thing actually unhealthy in one other individual. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally completely different than different individual’s physique. The identical organism or similar probiotic may be good for somebody and could possibly be dangerous for one more individual. And that’s the most important studying now we have had within the final six years.

Katie: Yeah, I like that you just introduced up the fecal microbiota switch as nicely. I’ve seen among the science on this and… you recognize, caveat, this isn’t one thing to try at dwelling but it surely’s fairly superb what they’re undertaking in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you may accomplish with out having to go to that excessive if you recognize what you’re working with. And for the final two years, I’ve been saying, you recognize, early on in well being and wellness, I might discover out data, learn research and be so excited and write about it, and I’ve realized increasingly over the past 15 years every thing is so customized and so individualized. And so now when folks ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “You recognize, I can inform you what I did but it surely’s not gonna work the identical for you. It may be an thought with the start line but it surely’s not gonna be your blueprint. Every of our blueprints is gonna be very, very completely different.”

Which is why I like now increasingly entry to those at-home testing whether or not or not it’s issues like Viome, even now blood testing out there at dwelling, genetic testing simply so we will have extra data and entry. And I’ve mentioned so many instances on right here we’re every our personal main healthcare supplier. On the finish of the day, it’s nice to work with docs however we’re every our personal main healthcare supplier. And I really feel like having instruments in our pocket that permit us be more practical at that may actually, actually make a distinction. So, let’s discuss slightly bit extra in regards to the personalization facet of this as a result of I additionally am curious…you recognize, I do know you mentioned every thing is so completely different. What’s good for one individual is perhaps not for one more. Are there any issues which can be type of universally unhealthy that you just’re discovering in Viome? Like, I might put perhaps processed vegetable oils on the don’t cross record, however I’m curious what you’re seeing within the knowledge.

Naveen: Yeah. So to start with, it’s actually fascinating. I feel you phrased it accurately. There is no such thing as a such factor as common wholesome meals. And meaning there isn’t any such factor that’s good for everybody. Meaning the identical meals may be good for you or unhealthy for somebody. Nonetheless, there are some common unhealthy issues you can know. So, there isn’t any common wholesome factor however there are universally unhealthy issues. Sugar is a kind of unhealthy issues. There is no such thing as a one who says, “The sugar is sweet for me, proper.” In order that’s really having a fried, you recognize, fried meals. So, all fried stuff, it’s simply unhealthy for everybody. Consuming a whole lot of sugar, it’s simply unhealthy for everybody. Nonetheless, what we discover most fascinating is that analyzing the human physique and analyzing primarily based on what’s going on and what’s dynamically altering in your physique…and I feel a whole lot of the people who find themselves listening to it, I need folks to know the distinction between a DNA which is static. So when folks do their DNA check, it tells you what’s inherently there in your physique. It doesn’t inform you what is definitely happening in your physique. Meaning…if, Katie, you permit me, I’m gonna clarify the DNA as a result of I feel to me lots of people get very confused about what DNA is.

So, each a part of our physique is similar DNA. Meaning you have a look at my hair, you have a look at my eyes, you have a look at my enamel, you have a look at my nails, you have a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Similar DNA. And the reply is there’s…when some genes are overexpressed, some genes are beneath expressed, the identical DNA can develop into eye, similar DNA can develop into nail, similar DNA can develop into pores and skin, similar DNA can develop into coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you’re writing is definitely what’s being expressed. It’s known as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each attainable factor that may occur. And that’s one factor.

So, what we do at Viome, Katie, is we have a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and inform you…some information to share with you in direction of the top. As soon as we perceive all that’s happening, we’re in a position to then inform you, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is just too excessive and the sulfide want sulfates to provide sulfide and the broccoli and cabbage are very excessive in sulfate so you need to minimize it down, proper.”

We are able to inform you that…lots of people will inform you go take vitamin B3. However vitamin B3’s really not good for you when you will have excessive uric acid manufacturing. So don’t take vitamin B3 when you have excessive uric acid manufacturing. Equally, everybody will inform you, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nonetheless, when your bile acid manufacturing may be very excessive, you don’t wish to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people suppose by some means taking NAD or NR, and NMN which is precursor to NAD is definitely enhance your longevity. It’s true for some folks it could do this, however for others it really will hurt you when you will have excessive mobile senescence, or when you will have excessive inflammatory exercise. You don’t wish to be taking further NAD as a result of that’s gonna enhance the mitochondrial biogenesis that’s going to extend extra free radicals, gonna enhance excessive mobile senescence, proper.

So, the concept actually is that it’s important to be taught what is going on earlier than you deal with your physique like a black field. And I feel you’ve mentioned it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who must know what is going on in our physique as a result of our main care physician…I don’t learn about you, Katie. After I go to my main care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the ailing, I’ll provide the tablet.” And that’s all they’re merely doing. They don’t must…they don’t care to know what’s inflicting that to occur in my physique. Like, you had Hashimoto, or in the event you had any kind of an autoimmune illness, the very first thing they inform you is simply take the immune suppression medicine and suppress the symptom. Not fear about what’s inflicting it, and that could be a elementary drawback that our healthcare system has is that our medical industrial complicated, everybody makes cash once we are sick and nobody makes cash once we are wholesome. And so, we determined to vary that. In my world of the longer term, Katie, we imagine that…I feel similar to you simply mentioned, the way forward for healthcare goes to be delivered at dwelling, not on the hospitals.

And the medicines of the longer term are gonna come from a farm, not a pharmacy. And that’s going to be the most important change you’ll begin to see us taking management of our personal well being. And I feel COVID has been one of many…I might say in the event you look again at COVID 10 years from now, will probably be the most important inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.

Katie: Completely. I feel so many good silver linings and educating moments in COVID and folks spent extra time at dwelling and with their households cooking dinner at dwelling. There have been a whole lot of nice outcomes, as arduous because it was for many individuals. I feel we will give attention to these positives. And I like your rationalization of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go slightly bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some massive advances since then. So, speak about type of the snapshot of what Viome is testing after which how persons are making modifications primarily based on that and what they’re seeing.

Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good but it surely didn’t inform us how these intestine modifications have been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID really, we launched our well being intelligence check that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t should go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re in a position to now have a look at each your intestine well being and your human host and in a position to now inform you what’s your organic age. And that tells you not solely, you recognize, how nicely or how poorly your physique is getting old in comparison with your chronological age.

So, to present you an thought, I’m now gonna be 63 in September and my organic age is right down to 50. And that tells you that actually that my physique is performing on the degree after I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra vitality than in reality I had after I was 50. And that merely tells you what your organic age is. Then we provide you with immune well being. Meaning how nicely are you protected towards in the event you have been to catch flu or chilly or any kind of pathogen, how nicely your physique is ready to shield itself? And that’s your immune well being. Your mobile well being. That tells you ways nicely your cells are in a position to endure the issues which can be happening within the human physique. Mitochondrial well being, that’s your vitality manufacturing unit. How nicely the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you’re feeling fatigued, you’re feeling drained. We provide you with clearly your intestine well being.

And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product known as full physique intelligence. And for the primary time, we’re gonna be analyzing all the way in which from high of your tube, your saliva, your stool and blood, all three on the similar time. And by taking a look at that, we’re additionally gonna be capable of present you some further insights corresponding to your coronary heart and metabolic well being. We’re gonna be providing you with your mind and cognitive well being. We’re gonna be capable of present you your oral well being corresponding to your gum well being, your enamel well being and all of the gum, you recognize…leaky gum as an alternative of simply leaky intestine. We’ll be capable of present you ways nicely your boundaries of your gums are performing in order that microbes should not going into your blood.

And different factor we do now which we didn’t do till a few 12 months in the past is if you do a check, not solely you get your deep perception what’s occurring in your physique and never simply inform you listed here are the meals which can be good for you and right here is why. Listed here are the meals you need to keep away from and why. We used to inform you listed here are the dietary supplements you need to take. Now we transcend that, Katie. We’re in a position to inform you you solely want 22 milligram of berberine every single day. You want 17 milligram of elderberry every single day. You want 79 milligram amylase every single day. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.

There is no such thing as a premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the way in which, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique modifications, we modify your dietary supplements on the similar time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you really want is butyrate now,” proper. And we actually are in a position to regulate your…as your physique is altering, we adapt the vitamin that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.

Different issues that I’m actually, actually enthusiastic about…and now we have not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a shopper you’ll be capable of spit in a tube and with 95% specificity and 90% sensitivity, we’ll be capable of inform you when you have any oral most cancers or throat most cancers. After which we’ll be capable of really join you with a physician to have the ability to do one thing about it. So, if you’re above…over 50 years outdated or have any historical past of smoking, vaping, chewing tobacco, you’ll be capable of really at dwelling do a check and truly know that you just’re not at a threat of growing a most cancers proper now. Otherwise you’re growing a most cancers proper now.

Katie: Yeah. That is so innovative and I feel simply to focus on what you mentioned, that is actually fascinating information of mainly machine studying and AI and this adaptive know-how. And since you’ve now examined 1000’s and 1000’s, in all probability lots of of 1000’s of individuals, then the algorithm has entry to all this data so it could actually proceed to get increasingly specialised and direct with the suggestions and be taught your personal physique over time. So, you’re getting this sort of ongoing, correct image which I feel is so fascinating.

Naveen: Yeah. So, Katie, now we have analyzed over 350,000 samples already. And that has given us this…you recognize, the a part of being the…a part of that Viome ecosystem is each single one who joins profit from the opposite 350,000 samples that now we have analyzed they usually contribute to the ecosystem, and our AI and machine studying is continually getting higher. And for each single one who joins profit themselves and advantages the humanity on the similar time as a result of now the extra we be taught, the higher suggestions we will make for everybody. So, earlier than we simply solely may have a look at your stool. Now we have a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the subsequent factor can be with urine. After which we’re gonna begin to take a look at different biomarkers in your physique. So, our suggestions get increasingly exact as we be taught increasingly in regards to the human physique. And our actual hope is, you recognize, in my lifetime we’ll be capable of perceive what causes the onset of a power illness and what causes them to progress and to have the ability to stop them from occurring within the first place, to diagnose them early once they really do occur, and to provide you with a treatment for these illnesses. Not merely handle them however to treatment them as soon as for all for every particular person. And that’s going to be the last word purpose of our life.

Katie: And I like that you just introduced up the interplay of all of the completely different microbiomes throughout the physique as nicely and the way you’re taking a look at all of those, as a result of a few of my early analysis was in oral well being and studying as an example that strep mutants and the micro organism that trigger gingivitis don’t each exist on the similar time. And it’s because now we have an oral microbiome. And if it will get out of steadiness in a single course or the opposite, you’re gonna find yourself with these issues. However the reply just isn’t sterilizing your mouth and killing all micro organism similar to we wouldn’t wish to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Similar factor with the intestine. And such as you mentioned, you’re taking a look at these all through the entire physique. I do know your daughter’s additionally doing a little fascinating analysis with the vaginal microbiome and I’m excited to speak together with her about that.

However I feel, like we talked about to start with, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra type of intricate knowledge we will get to make enhancements over time and naturally there could be a most cancers connection right here. You recognize, I’ve heard it mentioned that most cancers is a metabolic illness in some half. And this can be a means of…as a result of even inside a person, in the event you’re taking a look at a metabolic illness, you’re taking a look at, “Okay, we have to get blood sugar in examine. We have to get blood stress in examine. We have to get weight problems measures in examine.” However the way in which to try this’s gonna be completely different for each single individual.

Naveen: I feel it’s a metabolic and inflammatory illness. So, I imply, it’s precipitated…power irritation is a root reason for power illnesses. Nonetheless, what causes the irritation in our physique is completely different for every particular person. So regardless that it’s the irritation which may be on the root trigger however the underlying causes for that irritation are very, very completely different. And as you talked about, our daughter is, you recognize…has this firm known as Evvy, E-V-V-Y, which appears on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single girl ought to do this as a result of that’s actually…goes to be…you recognize, a lot of girls endure by way of most of the illnesses that we as males would by no means perceive. And that to some extent is, you recognize, largely reproductive organ and most of the instances the later analysis exhibits that vaginal microbiome is concerned in preterm start, within the well being of the child and all of the issues that you just talked about because the child goes by way of the start canal. All of the issues that come out in reality are contributory from the vaginal microbiome. So, my excessive advice…once more, I’m biased. I feel each girl ought to be doing the Evvy check, proper.

Now, coming again to the stuff you talked about that, you recognize, human well being is complicated however as soon as we perceive biochemical degree what’s going on, that’s the explanation as an alternative of taking a look at organisms and as an alternative of taking a look at DNA, we targeted on the gene expression or RNA. We targeted on what microbes are producing. Wanting on the complete physique. And I feel, Katie, I wanna level out that the merchandise that you just construct for oral well being are among the finest merchandise as a result of, to me, what’s the greatest gamechanger is folks thought the organisms have been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t do this. Whenever you kill the ecosystem in your mouth, it really destroys the entire digestive tract. And I wanna simply emphasize, you recognize, to folks when our moms informed us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too massive to go down our esophagus, proper. It was really was if you chew your meals, you’re permitting the oral microbiome in your saliva to truly predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.

So, the principle factor is that we have to permit the oral microbiome to predigest the feed so your small gut can now soak up the vitamins which can be already predigested. So, when you find yourself…so two issues it’s essential to take into consideration right here. And one is when you find yourself confused and you’re consuming your meals, it doesn’t get correctly digested and right here is why. If you find yourself confused, you’re in a struggle or flight response. And the primary factor that occurs if you’re in struggle or flight response is your digestive system shuts down. Keep in mind why it was designed. Whenever you’re operating away from a tiger, at the moment, the physique knew there isn’t any level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And in the event you turned lunch for another person, it didn’t matter. And in the event you survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you might digest your meals.

Whenever you come from work and you’re confused, what will we inform folks? Earlier than you eat, do the gratitude. Why is that? It’s since you wish to carry your physique from sympathetic mode into parasympathetic mode. Eliminate struggle or flight response. By taking the deep breath, by doing the gratitude, what you’re doing is definitely permitting your physique to have the ability to be able to digest the meals. Then if you chew your meals, you’re permitting your saliva and oral microbiome to truly predigest your meals. And these are easy methods we realized within the historic tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, you could not know that my mother and pop and our faith, they don’t eat after sundown. And I at all times marvel why would that be. And it seems as a result of it’s essential to have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of folks will get three, 4 hours of digestion. So, in reality telling that, you recognize…and that to me was actually the factor that we realized as a part of our tradition. Truly, seems we’re very scientific.

And I wanna come again to the oral merchandise. I feel folks have to be actually fascinated by oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…you recognize, probiotics. And the merchandise, among the merchandise that you’ve got, Katie, are designed to reinforce your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I feel everybody who’s listening to it to begin concentrate as a result of that’s the primary. Your mouth really is the start of your digestive tract. It’s not merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.

Katie: I completely agree. I feel very multifaceted however begin with the mouth is so essential. And I like a few the stuff you simply talked about about why we don’t digest meals if we’re confused and we all know, in fact, that People reside in a power state of stress usually. And one factor I’ve develop into keen on…you recognize, there’s a cause many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you may merely do respiratory workout routines. Do some field respiratory to calm your nervous system. I like that your loved ones naturally from a non secular perspective stopped consuming at sundown. I’ve realized in my very own life that I do nice after I time restricted eat and for a very long time I might wait and never eat until midday after which eat later within the day. And I observed after I shifted that to consuming and stopping by sundown, I really feel so significantly better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that if you’re sleeping, you may be therapeutic and your physique can get into autophagy and you’ll allocate sources to all of the pure processes the physique has in-built to maintain us wholesome.

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And I additionally wanna piggyback on what you mentioned about the identical cause we don’t wanna kill our oral microbiome is identical cause we don’t wanna kill our intestine micro organism as nicely however I nonetheless see folks type of hopping on the bandwagon of those actually harsh cleanses or in fact folks generally take antibiotics for causes whether or not they should or not. And people can each have a reasonably harsh affect on the intestine. And so, I’d love to speak about it. Perhaps if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine problem associated to essentially type of killing a few of these good micro organism. Clearly, Viome helps with this however type of, like, what may be executed? How can we assist repair it?

Naveen: So, very first thing is, you recognize, earlier than you go begin taking a whole lot of issues is to know, what’s the state of your intestine micro organism? So do a Viome check, perceive the place it stands. And then you definitely begin to take a look at what you…you recognize, we inform you what are the meals you need to eat. And once more, taking a whole lot of the fermented meals particularly if you’re attempting to repopulate or rebootilate your intestine microbiome, actually the issues ought to be diversification. So as an alternative of simply taking one kind of probiotics, you need to be taking kombucha, the kimchi, the…you recognize, all of the fermented meals you may presumably get your palms on. So, whether or not it’s a yogurt or, you recognize, a minimum of oat milk yogurt in the event you can. I imply, I’m a giant fan that I feel dairy…in reality for lots of the folks, dairy is the massive drawback. Now I’m not saying it’s for everybody however a whole lot of the folks, dairy could possibly be a giant drawback. And the mammalian merchandise really could possibly be a giant drawback for some folks and never for others.

So, I’m not the one that is preaching veganism right here in any respect. What I’m saying is know what is sweet for you. There are lots of people who can eat crimson meat for all of their life and reside to be 100, and the explanation for that’s crimson meat accommodates clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the center illness. So, it’s not the crimson meat that causes the center illness. It’s the byproduct of how the crimson meat is digested in some those who produce TMA. So, in case your TMA manufacturing is low, you need to eat crimson meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to know, don’t merely ban meals and complete class of meals.

One other factor that we realized…we revealed a paper having analyzed over 100,000 folks at the moment on getting old. And what we discovered, Katie, that you could be discover actually fascinating is individuals who have been on these fad diets like, you recognize, keto weight loss program or paleo weight loss program have been the worst offender of their organic age. The individuals who have been on keto weight loss program in reality have been three to 5 years older than their chronological age and the identical is true for paleo weight loss program. It seems that people who find themselves on balanced weight loss program, meaning they have been consuming their carbs however not quite a bit however they have been consuming their regular carbs, they have been consuming their protein, they have been consuming their fats they usually have been consuming the protein, they have been far more balanced, have been really higher off biologically than chopping out the entire nutrient group utterly.

Katie: That is sensible, that we want the variability. And I’ve realized increasingly as nicely that I feel the simplistic model all of us realized, hopefully realized at school was about simply type of energy in, energy out. And I’ve heard it mentioned, you recognize, our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra various and essential than that.

And what’s subsequent for Viome? I’m curious as a result of I do know you’re always doing analysis right here, and such as you mentioned, your purpose is to sort out power illness in its entirety. So, what’s within the pipeline for you guys?

Naveen: Truly, I discussed that subsequent check we’re launching in June is a full physique intelligence. We’re launching a most cancers detect check. And we’re making our dietary supplements and probiotics increasingly exact for each particular person since we make it for every particular person. We’re, you recognize, attempting to do further checks now and our purpose is to launch within the subsequent six months one other check which is gonna be extra, like, a proteomics check as a result of the issues we can not see within the blood as a result of they’re produced someplace else. So, can we measure issues, you recognize, the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict when you have a leaky intestine by taking a look at LBP, by taking a look at CRP which really is completed within the liver? So, we’re going to have the ability to really measure further issues along with simply those that we’re measuring, and the extra data we will be taught, the higher suggestions we make. So, our hope is to proceed to launch these checks that give us higher and higher insights and meaning we will make increasingly exact advice for every particular person.

Final purpose actually is to know…as you say, the human physique is a chemistry lab. Now we have mainly biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor folks want to know that the gene expression tells you what biochemistry is occurring within the physique. And that’s a cause…and in reality, Viome is the one firm that does have a look at the gene expression as a result of there isn’t any different firm that has this know-how. And I feel individuals who have listened to your earlier podcast, we talked about, this explicit know-how got here out of Los Alamos Nationwide Lab the place they’d the laboratory for biodefense undertaking. And that’s the explanation nobody else can do it as a result of it took 10 years and multibillion {dollars}’ value of sources to develop this know-how. Sadly, we have been very lucky to have the ability to get the license to have the ability to use this know-how to assist the humanity get higher. And if our mission was merely to make cash, we’d not have been in a position to license this know-how, proper.

So, the actual fact at present we’re merely targeted on making each single individual be higher. You recognize, our mission on day one was what if we may perceive the human biology at a molecular degree so we will stop, diagnose early and treatment these power illnesses together with most cancers and getting old? And I feel a whole lot of the individuals who have heard you and I discuss previously, you recognize that I misplaced my dad to most cancers and that was one of many greatest motivator for me as a result of if I had began this firm half a decade earlier than I did, I may have probably saved my dad. And, you recognize, having watched him undergo that ache or struggling by way of most cancers I spotted that regardless that I couldn’t save him, I may dedicate my life to saving everybody else. And that can be my means of letting him know that, you recognize, I’m so happy with what he…how he raised us as a baby and giving us every thing now we have so we’re in a position to save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or melancholy, nervousness or most cancers.

And my hope actually is that in our lifetime we’ll completely eradicate most cancers from the human physique. And if I have been to make a prediction at present, I’ll inform you inside a decade I feel we’ll eliminate most cancers from the human physique.

Katie: That’s a giant declare and I hope we’re on observe for that as nicely. I’ve misplaced two prolonged relations within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m positive the power stress of the final couple of years just isn’t serving to that drawback. So, I’m grateful that there are sources such as you, and I’ve executed Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna ensure that…I do know you’ve supplied a reduction code for the Viome testing. In order that hyperlink can be within the present notes for you guys listening at wellnessmama.fm. You will discover the low cost code and the hyperlink on to it there. And to ensure I respect your time, there’s a pair final questions I might like to ask you. The primary being if there’s a e-book or a lot of books which have profoundly influenced your life. And in that case, what they’re and why?

Naveen: Yeah, so the e-book that actually influenced me…there’s a e-book by Clayton Christensen, you recognize. I like the person and I noticed him earlier than he died. The e-book he wrote, “How Will You Measure Your Life?” And to me it was such a profound e-book which tells you that it’s important to be 100% sincere. You can’t be 99% sincere as a result of as soon as you’re taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll at all times be another excuse to make an exception. And so, it’s important to focus your self to by no means, ever compromise in your rules that you just stand for. And that was simply completely a wonderful e-book I learn.

You recognize, the e-book that additionally…I imply, clearly I wrote a e-book known as “Moonshots” that’s actually about making a mindset of abundance fairly than a mindset of shortage. And the basic perception that I’ve is that there’s nothing that people should not able to doing if we really get our mindset to imagine we will. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to determine whether or not they can or they will’t. That after you imagine one thing is not possible, it turns into not possible for you and nobody else. And so, you’re utterly in management. The one factor you may’t do is what you may’t think about. All the pieces else is feasible.

Katie: I like that. I do know you and I each elevate our children with that mindset and yours are older and doing superb issues out on the earth already and mine are to start with levels of that. And lastly, what parting recommendation would you want to go away with the viewers at present? May very well be associated to one thing we’ve talked about or fully unrelated.

Naveen: I might say dream so massive that individuals suppose you’re loopy. Meaning by no means let somebody inform you you can’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self just isn’t about being self-conceited. Loving your self is about not in search of another person’s approval to do the issues that imply quite a bit to you. Comply with your coronary heart, comply with your intestine, hearken to your intestine and comply with what it tells you. Discover a objective in life. When you discover a objective in life, you’ll by no means ever suppose it’s work. I rise up every single day at 4 a.m., and that’s my recommendation to everybody. Everytime you rise up within the morning, in the event you’re not leaping out of the mattress, you need to give up what you’re doing as a result of that’s not your calling, as a result of if you discover your calling, you’ll not be mendacity down within the mattress. You soar out of the mattress with pleasure wanting to unravel that drawback.

And, Katie, I simply wish to reiterate, I met your children and I do know I bear in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your children are going to truly transfer this humanity ahead. You’re elevating these kids with the mindset that every thing they wish to do, they will. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it a whole lot of instances. Like, once we elevate our youngsters, we inform them, “Our love for you is unconditional however our approval just isn’t.” And what meaning is solely is that we’ll at all times love you, we’ll at all times be there for you, however I’m not gonna inform you I’m happy with you except you do issues that make us happy with you. And that’s actually the factor about telling the youngsters that their success won’t ever be measured by how a lot cash they’ve within the financial institution. Will probably be measured by what number of lives they enhance. And the humility is an indication of success as a result of in the event you nonetheless have iota of vanity left in you, meaning you’re nonetheless attempting to show one thing to your self or another person. And humility tells you now not have to try this, proper. And that could be a true signal of success. And all I can say is I’m so happy with each one in all your kids, Katie. And I can not anticipate them to develop up and truly do issues that can make our youngsters’s and grandchildren’s life higher.

Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over really parenting earlier than we ever talked about well being. And we share that similarity. I inform my children every single day, “I like you unconditionally and there’s nothing you ever should do to earn my love and there’s nothing you might ever do that might take away from my love.” However you’re proper. Additionally, I need that, like, their pleasure to come back from within, like…and I inform them usually, “You will need to really feel actually happy with how arduous you labored and you should…” As a result of I need them to have that inside them and that self-love.

And that is why I’m so grateful each single day that I get to speak to our viewers that’s listening at present of mothers, as a result of I feel mothers have such a tremendous distinctive capacity to essentially shift the way forward for humanity by how we guardian our children and by serving to kind these future leaders. And for individuals who aren’t already conversant in you, I might encourage you to hearken to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these superb issues after which now serving to your children on their life journeys and your spouse in her personal proper is unimaginable as nicely. So very grateful to your complete household and for all that every one of you’re doing on the earth and to your time at present. I understand how busy you’re and I’m so grateful you took the time to be right here.

Naveen: Oh, Katie, it’s at all times an honor and a pleasure to be talking with you, and I’m wanting ahead to our subsequent dialog.

Katie: And thanks, as at all times, to all of you for listening and sharing your Most worthy sources, your time, your vitality, and your consideration with us at present. We’re each so grateful that you just did. And I hope that you’ll be part of me once more on the subsequent episode of the “Wellness Mama” podcast.

 

In the event you’re having fun with these interviews, would you please take two minutes to go away a score or evaluation on iTunes for me? Doing this helps extra folks to seek out the podcast, which suggests much more mothers and households may gain advantage from the data. I actually admire your time, and thanks as at all times for listening.

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